As HIV turns into a chronic infection, an increasing number of HIV-inflamed patients are journeying to malaria-endemic areas. Association of malaria with HIV/AIDS may be clinically intense. Severe falciparum malaria is a clinical emergency this is associated with high mortality, even if dealt with in an Intensive Care Unit. This article describes two cases of HIV-high quality patients, who again from malaria-endemic regions and supplied a parasitaemia > 5% of erythrocytes and clinical signs and symptoms of severe falciparum malaria, each with > 350 CD4 cell rely/μl, absence of chemoprophylaxis and a hit response. Factors like drug interactions and the viable implication of anti-malarial remedy bioavailability are all specifically thrilling in HIV-malaria co-infections.