From a pharmacochemical perspective the current foe of leprotics too as could be typical movements in the chemotherapy of disease are examined. Of the basic foe of leprotics, which are utilized these days — dapsone, rifampicin, clofazimine, isoniazide, ethionamide and prothionamide — the piece of development, the focal issues in their application and potential outcomes to make improved assortments are assessed. Considering the science of Mycobacterium leprae, the objective frameworks for new foe of leprotics are perceived. These structures combine the cell divider, the catabolism of open oxygen species, the ingestion systems of carbon sources, the amino dangerous osmosis and the take-up of iron. Two potential new lead structures from different fields, 4-quinolones and mycobacterial ribonucleotide reductase inhibitors are introduced.