Pharmaceutical investigation is a part of down to earth science that includes a progression of procedure for recognizable proof, assurance, measurement and cleaning of a substance, partition of the segments of an answer or blend, or assurance of structure of synthetic compounds. The substance might be a solitary compound or a blend of mixes and it might be in any of the dose structure. The substance utilized as pharmaceuticals are creatures, plants, miniaturized scale living beings, minerals and different engineered items. The example to be examined is called as investigate and based on size of test, they can be delegated macro(0.1 g or more), semi miniaturized scale (0.01 g to 0.1 g), micro(0.001 g to 0.01 g), sub small scale (0.0001 g to 0.001 g), ultra micro (underneath 10-4 g), follow analysis(100 to 10000 ppm). Among all, the semi miniaturized scale investigation is generally utilized. Subjective investigation is performed to build up structure of regular/engineered substances. These tests are performed to demonstrate whether the substance or compound is available in the example or not. Different subjective tests are discovery of developed gas, arrangement of hastens, limit tests, shading change responses, dissolving point and breaking point test etc. Quantitative investigative procedures are for the most part used to measure any compound or substance in the example. These strategies are situated in (a) the quantitative presentation of appropriate synthetic response and either estimating the measure of reagent added to finish the response or estimating the measure of response item acquired, (b) the characteristic development of a substance through a characterized medium under controlled conditions, (c) electrical estimation, (d) estimation of some spectroscopic properties of the compound.In gravimetric examination, a substance to be resolved is changed over into an insoluble encourage in the most flawless structure, which is then gathered and gauged. It is the tedious process.In electro gravimetry, electrolysis of the example is completed on the anodes is weighed after drying. Thermo gravimetry (TG) records the adjustment in weight, differential warm investigation (DTA) records the distinction in temperature between test substance and a latent reference material, differential filtering calorimetry (DSC) records the vitality expected to set up a zero temperature contrast between a test substance and reference material. Gasometry includes estimation of the volume of gas developed or assimilated in a compound reaction. Some of the gases which are examined by Gasometry are CO2 , N2O,cyclopropane, amyl nitrate, ethylene, N2, helium and so on.