Peripheral artery disease also called peripheral arterial disease is a common circulatory problem in which narrowed arteries reduce blood flow to your limbs. When you develop peripheral artery disease, your extremities — usually your legs — don't receive enough blood flow to keep up with demand. This causes symptoms, most notably leg pain when walking. Peripheral artery disease is also likely to be a sign of a more widespread accumulation of fatty deposits in your arteries. This condition may be reducing blood flow to your heart and brain, as well as your legs.