Preventive Medicine is a global intellectual journal that encourages prompt publication of original articles on the science and practice of disease hindrance, health promotion, and public health policymaking. Preventive medicine aims to reward innovation. It will favor perceptive empiric studies, thoughtful explorations of health knowledge, and unsuspected new angles for existing hypotheses, study randomised controlled trials, and impartial systematic reviews. Preventive Medicine's final goal is to publish research work that may have an impression on the work of practitioners of disease hindrance and health promotion, furthermore as of connected disciplines.

Medulloblastoma and primitive neuroectodermal tumors (PNETs) are the most common malignant brain tumors in children. The concern for late sequelae of neuraxis irradiation and the obligation to improve disease-free survival in children who harbor malignant brain tumors has led to the additional provision of systemic chemotherapy to standard- and reduced-dose radiotherapy, as well as to the evaluation of alternate modes of radiotherapy delivery. Analysis of evidence has suggested that chemotherapy has an impact on length of survival in children with medulloblastoma and PNETs. The question remains as to whether chemotherapy combined with reduced-dose radiotherapy provides greater benefit than standard-dose radiotherapy alone, and which subset of children the treatment most benefits. Also unanswered is the question of whether chemotherapy can serve as the primary treatment in infants with these lesions. In an attempt to help answer these questions, the authors review the major chemotherapy and radiotherapy trials for newly diagnosed patients and those with recurrent medulloblastoma and PNETs