Treatment of schizophrenia should be complex (psychopharmacology, psychotherapy, educative programs for patients, rehabilitation of social and communication skills,promoting the adherence to treatment, monitoring of early side effects of treatment, self helping groups etc) and complex therapy of schizophrenia should not be based only on pharmacotherapy. This complex approach can influence effectiveness of treatment as a whole. When pharmacoresistency in a patient with schizophrenia has been proved, then augmentation of dosage, combination of antipsychotics, combination with auxilliary medication, clozapine, electroconvulsions or repetitive transcranial magnetic stimulation can be helpful in treatment. The goal of peer-review is to assess the quality of articles submitted for publication in a Scholarly Open Access Journals. Peer-reviewed articles provide a trusted form of scientific communication.