Pancreatic Auto Islet Transplantation is a strategy used to keep up insulin creation and emission in patients with ceaseless pancreatitis that are experiencing a complete pancreatectomy, or expulsion of the whole pancreas. When all other clinical treatments neglect to control the torment, evacuation of the pancreas might be a choice; anyway it can leave an individual diabetic, which implies that the body can no longer control glucose levels, and will require serious testing of glucose and infusions of insulin. The pancreas is an organ, situated in the upper stomach hole, behind the stomach, liver and colon. Inside the pancreas, specific bunches of cells known as islets produce insulin, which keep up solid glucose levels. The pancreas likewise creates catalysts to help digest food. In request to reduce torment and keep up insulin creation, the pancreas is expelled from the body, handled and the islets are reaped. When the pancreas is evacuated, it is put in an answer and put into a machine where the pancreas is processed. The islets are then mixed into the patient's liver. Inside a brief timeframe, the islets are relied upon to begin creating insulin. Pain control is one of the most testing viewpoints in the administration of ceaseless pancreatitis. Absolute pancreatectomy can effectively mitigate the immovable stomach torment in these patients yet will definitely bring about insulin-subordinate diabetes. Islet autotransplantation intends to safeguard, quite far, the insulin secretory capacity of the islet cell mass along these lines decreasing (or in any event, evacuating) the necessity for exogenous insulin organization after an all out pancreactomy. Notwithstanding the generally modest number of focuses ready to play out these systems, there are significant specialized varieties in the subtleties of their methodologies. The point of this audit is to give subtleties of the current careful practice for all out pancreatectomy joined with islet autotransplantation, and blueprint the potential focal points and disservices of the varieties received in each inside. In 80% of patients, the torment from pancreatitis is eased by an absolute pancreatectomy. After some time, a few patients might be diabetic and should take insulin to keep up sound glucose levels. All patients will take pancreatic proteins to help digest food after medical procedure. Careful intercession for constant pancreatitis might be demonstrated in patients with crippling torment stubborn to clinical administration. The decision of activity reflects suspicions about the basic system of agony and depends on anatomic conditions, for example, pipe widening, conduit injuries, intraductal calculi, or the nearness of a provocative mass. A decompressive technique, for example, horizontal pancreaticojejunostomy might be fitting for patients with huge pipe malady, in whom the component of agony is ventured to identify with pipe obstacle. Then again, a pancreatic resection, for example, pancreaticoduodenectomy might be suitable for patients with a predominant incendiary mass in the leader of the pancreas. In suitably chose patients worked in experienced focuses, mortality is typically under 2%, and complete or generous help with discomfort can be accomplished in around 80–90%. A few patients with hard-headed difficult interminable pancreatitis have no conspicuous ordinary careful alternative since they do not have an appropriate anatomic objective for resection or decompression. Others have tireless or intermittent agony in spite of usable intercession, or crippling successive assaults of intense pancreatitis without other restorative alternatives. It is for this subset of patients that aggregate or consummation pancreatectomy with or without islet autotransplantation might be a sensible choice.