There's uncertainty regarding the selection from variable recommendations for medicine management of constipation and a variable clinical observe in palliative care settings. the aim of the review was to gauge the present recommendations of medical care tips and to see the effectiveness and safety of laxative administration for the management of constipation in palliative care patients. Despite the clinical importance, there are restricted information on the efficaciousness and safety of laxatives in palliative care patients. The social acceptableness varies from country to country, however overall, oral laxatives ought to, wherever attainable, be utilized in preference. general opioid antagonists, like Narcan and methylnaltrexone are studied in few clinical trials. there's a dearth of neat, prospective, randomized controlled trials with giant enough numbers of patients laid low with constipation and treated with medicine strategies. There is restricted information accessible on the traditional medicine treatment of constipation in palliative care patients because of insufficient randomized controlled trials. However, subcutaneously administered methylnaltrexone was found to be effective in aiding of laxation and well tolerated with restricted or transient facet effects in palliative care patients.