The impact factor of journal provides quantitative assessment tool for grading, evaluating, sorting and comparing journals of similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period, and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years. Successful viral infection depends on the virus’ capacity to evade the host’s interferon (IFN)-mediated innate immune response, and thereby prevent the establishment in cells of an antiviral state. Viral evasion of IFN immunity is mediated by multifunctional, virus-encoded IFN-antagonist proteins, which interact with diverse host factors, including intracellular signalling and effector molecules of the IFN system; thus, IFN-antagonists represent potential targets for antiviral therapies, but the molecular events underlying their functions are currently poorly defined.Using live-cell imaging, molecular/cell biology and reverse genetics approaches with animal infection models, we have investigated the functions of the archetypal IFN-antagonist, rabies virus P protein, finding that it undergoes intricately regulated subcellular trafficking involving numerous sequences for interaction with the host cell’s nuclear transport machinery, cytoskeletal components, and IFN signalling/effector molecules.