In the field of molecular biology, nuclear receptors are a class of proteins found within cells that are responsible for sensing steroid and thyroid hormones and certain other molecules.  Nuclear receptors are a family of ligand-regulated transcription factors that are activated by steroid hormones, such as estrogen and progesterone, and sundry other lipid-soluble signals, including retinoic acid, oxysterols, and thyroid hormone. A class I nuclear receptor (NR), in the absence of ligand, is located in the cytosol. Hormone binding to the NR triggers dissociation of heat shock proteins (HSP), dimerization, and translocation to the nucleus, where the NR binds to a concrete sequence of DNA kenned as a hormone replication element (HRE). Nuclear hormone receptors are ligand-activated transcription factors that regulate gene expression by interacting with categorical DNA sequences upstream of their target genes. Proteins of the nuclear receptor super-family are single polypeptide chains consisting of three major domains: a variable amino-terminal domain, a highly conserved DNA-binding domain (DBD), and a less conserved carboxyl-terminal ligand binding domain (LBD). A hormone receptor is a receptor molecule that binds to a categorical hormone. There are two main classes of hormone receptors. Receptors for peptide hormones incline to be cell surface receptors built into the plasma membrane of cells and are thus referred to as trans membrane receptors. The top online publishing journals publish articles which are cited as references by many authors in their work. The citations are consequential for a journal to get impact factor. Impact factor is a quantification reflecting the average number of citations to recent articles published in the journal. The top online publishing journals publish articles which are cited as references by many authors in their work. The citations are consequential for a journal to get impact factor. Impact factor is a quantification reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more paramount than those with lower ones. Indexing provides facile access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, germane and reliable information predicated on the current research and development on a variety of subjects. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, germane and reliable information predicated on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated utilizing citations not only from research articles but additionally review articles editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and endeavour to increment their number expeditiously. Impact factor plays a major role for the particular journal. The nuclear receptors is peer reviewed journals works to publish most reliable and consummate source of information regarding advance revelations and development in the path of nuclear receptors.