Newcastle disease, formerly exotic Newcastle disease, maybe a contagious viral avian disease affecting many domestic and wild bird species; it's transmissible to humans. Though there are rare cases where the disease gives a light fever and/or conjunctivitis. Its effects are most notable in domestic poultry thanks to their high susceptibility and therefore the potential for severe impacts of an epizootic on the poultry industries. It is endemic to many countries.

Exposure of humans to infected birds (for example in poultry processing plants) can cause mild conjunctivitis and influenza-like symptoms, but the Newcastle disease virus (NDV) otherwise poses no hazard to human health. No treatment for NDV is known, but the use of prophylactic vaccines and sanitary measures reduces the likelihood of outbreaks.