Neurosyphilis alludes to infection of the focal sensory system in a patient with syphilis and can happen at any stage. In the time of present day anti-infection agents most of neurosyphilis cases have been accounted for in HIV-tainted patients. Meningitis is the most well-known neurological introduction in early syphilis. Tertiary syphilis side effects are only neurosyphilis, however neurosyphilis may happen at any phase of infection. To analyze neurosyphilis, patients experience a lumbar cut to get cerebrospinal liquid (CSF) for investigation. The CSF is tried for antibodies for explicit Treponema pallidum antigens. The favored test is the VDRL test, which is here and there enhanced by fluorescent treponemal counter acting agent assimilation test. The signs and indications of neurosyphilis fluctuate with the illness phase of syphilis. The phases of syphilis are sorted as essential, auxiliary, inert, and tertiary. Note that neurosyphilis may happen at any phase of infection.