Despite the fact that the investigations of particle channel structure-work relationship have consistently been the most sought after spots, the posttranslational change forms, for example, glycosylation, phosphorylation, and elective grafting related with channel capacities, have additionally been explored. Z. Liu et al. recommended that sodium channel-explicit neurotoxic poisons, a group of long-chain polypeptides beginning from venomous creatures, conceivably share restricting destinations neighboring glycosylated areas of VGSCs (voltage gated sodium channels). Subsequently, a connection among poisons and glycosylated VGSCs may ideally join the battle to move toward the job of glycosylation in balancing VGSC-included neuronal system action.

Aside from voltage-gated particle channels, ionotropic glutamate receptors named ligand-gated particle channels, for example, NMDA, AMPA, and kainate receptors, are additionally thought to intervene a great part of the excitatory neurotransmission in the cerebrum. D. R. Morris and C. W. Levenson talked about the job of the excitotoxic convergence and zinc aggregation, the components answerable for its cytotoxicity, and various issue of the focal sensory system connected to these neuronal particle channels and zinc poisonousness. The top to bottom looks into in harmful synthetic substances focused on neuronal receptors may ideally assist with creating systems to square zinc-interceded harm and forestall bothersome results.