The plasma cells are a type of white blood cell in the bone marrow. With this condition, a group of plasma cells becomes cancerous and multiplies. The disease can damage the bones, immune system, kidneys and red blood cell count. Symptoms may not be present or may be non-specific, such as loss of appetite, bone pain and fever. Treatments include medication, chemotherapy, corticosteroids, radiation or a stem-cell transplant. Top journals are intended to reflect the place of a related field, the difficulty of being published in that journal, and the prestige in association with it. They have been introduced as official research development tools in several countries.