When cancer involves plasma cells, the body keeps producing more and more of these cells. The unneeded plasma cells all abnormal and exactly alike are called myeloma cells, Multiple myeloma is a type of cancer that affects certain white blood cells called plasma cells. Plasma cells are part of the immune system, which helps protect the body from infection and disease. Like all white blood cells, plasma cells begin their development in the bone marrow, the soft, spongy tissue that fills the center of most bones High-impact journals are those considered to be highly influential in their respective fields. The impact factor of the journal provides a quantitative assessment tool for grading, evaluating, sorting, and comparing journals of a similar kind. It reflects the average number of citations to recent articles published in science and social science journals in a particular year or period and is frequently used as a proxy for the relative importance of a journal within its field. It is first devised by Eugene Garfield, the founder of the Institute for Scientific Information. The impact factor of a journal is evaluated by dividing the number of current year citations to the source items published in that journal during the previous two years.