Musculoskeletal/tuberculosis (TB) represents roughly 10% of all extrapulmonary TB cases in the United States and is the third most regular site of extrapulmonary TB after pleural and lymphatic ailment. Vertebral inclusion (tuberculous spondylitis, or Pott's sickness) is the most well-known sort of skeletal TB, representing about portion of all instances of musculoskeletal TB. The introduction of musculoskeletal TB might be tricky over an extensive stretch and the determination might be slippery and postponed, as TB may not be the underlying thought in the differential conclusion. Accompanying aspiratory inclusion may not be available, consequently befuddling the conclusion significantly further. Early determination of bone and joint ailment is essential to limit the danger of disfigurement and upgrade result. The presentation of fresher imaging modalities, including MRI (imaging method of decision) and CT, has upgraded the indicative assessment of patients with musculoskeletal TB and for coordinated biopsies of influenced regions of the musculoskeletal framework. Getting proper examples for culture and other demonstrative tests is fundamental to build up a conclusive analysis and recuperate M. tuberculosis for vulnerability testing. A sum of 6 to 9 months of a rifampin-based routine, similar to treatment of pneumonic TB, is suggested for the treatment of medication defenseless musculoskeletal infection. Randomized preliminaries of tuberculous spondylitis have exhibited that such regimens are effective. These information and those from the treatment of pneumonic TB have been extrapolated to frame the premise of treatment routine proposals for different types of musculoskeletal TB.