The drugs utilized in WHO-MDT are an amalgamation of rifampicin, clofazimine and dapsone for MB leprosy patients and rifampicin and dapsone for PB leprosy patients. Among these rifampicin is the most paramount antileprosy drug and ergo is included in the treatment of both types of leprosy. Treatment of leprosy with only one antileprosy drug will always result in development of drug resistance to that drug. Treatment with dapsone or any other antileprosy drug utilized as monotherapy should be considered as unethical practice. Leprosy is an archaic disease, which was treated by local application of chaulmoogra/hydnocarpus oil during prechemotherapeutic era. Since 1940, dapsone was the only chemotherapeutic agent utilized for treatment of leprosy for about three decenniums. Perpetuated, interrupted and inadequate utilization of dapsone monotherapy, leads to development of dapsone-resistant cases. Usefulness of clofazimine was kenned in 1962. Prelude of rifampicin--a puissant bactericidal drug in 1970 has opened the avenues of multidrug therapy to treat leprosy. Multidrug therapy recommended by World Health Organisation came into practice after 1982. The regimen followed now is for duration of 6 months in paucibacillary and for the duration of 12 months in multibacillary cases. It is proven to be safe and efficacious. Multidrug therapy for leprosy cases is available in the form of blister calender packs and is available free of cost at all regime health facilities. Albeit more incipient drugs such as ofloxacin, minocyclin, clarithromycin, etc, are kenned now but they are utilized as alternative drugs if a component of amalgamation in multidrug therapy becomes contra-denoted. This article brings the details of sundry drugs used under multidrug therapy, their characteristics, side-effects, regimens and alternative drugs available for treating leprosy. To increment the overtness and facilitate of avail of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving accommodations. Indexing provides facile access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are consequential for a journal to get impact factor. Impact factor is a quantification reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more paramount than those with lower ones. Indexing provides facile access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, pertinent and reliable information predicated on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated utilizing citations not only from research articles but withal review articles (which incline to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and endeavor to increment their number expeditiously. Impact factor plays a major role for the particular journal.