Mucins are high-molecular-weight glycoproteins expressed throughout the alimentary canal , with a key role in mucosal protection and performance . In gastric cancer expression of MUC5AC and MUC1 is reduced and denovo expression of MUC2 occurs. The development of intestinal metaplasia (IM) within the stomach is related to distinct changes within the mucin phenotype. Complete IM (type I), which is histologically characterized by a well-defined brush-boarder, displays markedly reduced MUC1, MUC5AC and MUC6 but strong, uniform, de novo MUC2 expression. There was no association between mucin expression and survival when considering overall gastric cancers or the advanced gastric cancer subtype. In particular, MUC5AC-positive early gastric cancers resulted in longer survival than did people who didn't express MUC5AC (P = .009). Mucins are high-molecular-weight epithelial glycoproteins that are heavily glycosylated with numerous oligosaccharide side chains linked to a protein backbone called apomucin. Gastric cancer may be a disease during which malignant (cancer) cells form within the lining of the stomach. Age, diet, and stomach disease can affect the danger of developing gastric cancer. Symptoms of gastric cancer include indigestion and stomach discomfort or pain. Tests that examine the stomach and esophagus are wont to diagnose gastric cancer. For the past several decades, rates of cancer within the main a part of the stomach (stomach body) are falling worldwide.