Innovations in molecular modeling are tremendous, some of the innovations in molecular modeling are, advanced industry quality computational chemistry and molecular modeling resources. High throughput virtual screening o diverse libraries for novel therapeutics targets, structure based pharamacophore design, Scaffold hopping and de novo design. Utilize state of the art software from Schrodinger, Tripos and Accelrys with parallel processing LINUX-based workstations. Molecular modeling focuses on insilco drug protein interactions, arrangement of amino acids sequences. Identifications of epitope, gene expressions, and also biomarker discovery could also be discovered through molecular modeling.