Biocatalysis has been used widely in the pharmaceutical industry to make small molecule drugs. Enzymes are excellent catalysts that are increasingly being used in industry and academia. It is focused mainly at synthetic organic chemists with limited experience using enzymes and provides a general and practical guide to enzymes and their synthetic potential, with particular focus on recent applications. Using the catalytic power of enzymes to perform highly stereo selective organic transformations has been the basis of the ever-expanding field of biocatalysis. Enzymes have evolved over millions of years to be some of the best catalysts available to chemists. Now, through advances in molecular and synthetic biology, chemists are able to redesign the active sights of many enzymes to fit their synthetic needs. It’s only in the last 20 years or so that synthetic labs have come around to the B-word. Using the DNA sequence of known enzymes, it is possible to search for sequences which are similar. If these same sequences are found, it can then be placed into a different organism and then made to see if the sequence does in fact code for an enzyme.   Maim of the Open access policies are highly appreciable, accepted and adaptable to the criteria that have been prescribed by the international agencies.