Headache cerebral pain is a ceaseless, hereditary, neurologic confusion including anomalous tangible preparing. Headaches are regularly incapacitating, prompting emotional way of life changes and confinements for the migraineur. Clinicians must be sure about their determination and treatment of headache cerebral pains if tolerant results are to improve.The pathophysiology of headache migraine has not been unmistakably explained. Early hypotheses placing that headache and headache atmosphere were exclusively because of vasodilation and vasoconstriction of cranial vasculature have been generally disproven. Late hypotheses accentuate the significance of close collaborations between meningeal/cranial vessels and nerves; neuropeptides; and CNS structures, particularly the trigeminal neurovascular unit and the brainstem.1,2 The migraineur's mind in all probability has useless slipping torment restraint, is hyperexcitable, and has a diminished agony edge. A few creators have talked about the pathophysiology of migraine.1,2 DIAGNOSTIC CRITERIA The finding of headache cerebral pain is clear and follows the rules built up by the International Headache Society (IHS) in its second release of the International Headache Classification (IHCD-2)3 (Table 1). Headache migraine is regularly portrayed by moderate to extreme one-sided pounding torment and joined by sickness or regurgitating, with sensitivities to lights and sounds. Note, in any case, that not every one of these components need be available for a finding of headache.