Metagenomics, or the way of life autonomous genomic examination of a collection of microorganisms, can possibly respond to basic inquiries in microbial biology. This audit depicts progress toward understanding the science of uncultured Bacteria, Archaea, and infections through metagenomic investigations. Uncultured microorganisms involve most of the planet's organic decent variety. Microorganisms speak to two of the three spaces of life and contain immense decent variety that is the result of an expected 3.8 billion years of development. By portraying the plenitudes of qualities having a place with these genera, metagenomic sequencing uncovered the varieties of microbial wealth and assorted variety under various natural conditions. To get full subtleties of gut microbiota, including microorganisms, parasites, bacteriophages, and helminths, in goliath pandas (GPs), we made a thorough microbial genome database and utilized metagenomic groupings to adjust against the database.