Metabolic syndrome is a cluster of conditions that occur together, increasing your risk of heart disease, stroke and type 2 diabetes. These conditions include increased blood pressure, high blood sugar, excess body fat around the waist, and abnormal cholesterol or triglyceride levels. Metabolic diseases affect the ability of the cell to perform critical biochemical reactions that involve the processing or transport of proteins (amino acids), carbohydrates (sugars and starches), or lipids (fatty acids). Metabolic disease. Metabolic syndrome is a group of five risk factors that increase the likelihood of developing heart disease, diabetes, and stroke. Abnormal chemical reactions that hinder metabolic processes; a disease in the liver, pancreas, endocrine glands, or other organs involved in metabolism