Melatonin may be helpful for insomnia and jet lag. However, it has a theoretical risk for people with MS because it may stimulate the immune system. It would be reasonable for people with MS to avoid melatonin. If melatonin is used by people with MS, high doses and long-term use should probably be avoided. Circadian biology has rendered some interesting research that shows melatonin has a neuroprotective role in processes that can lead to demyelisation and inflammatory response typical in MS. Simply put, the less melatonin one produces can lead to a higher frequency of symptoms and even relapses.