Fungi make important contributions in managing disease in humans and animals. Penicillin is based on fungi. Fungi are involved in the industrial processing of more than 10 of the 20 most profitable products used in human medicine. Drug discovery and research are ongoing.Uses of fungi in medicine include micafungin, an antifungal agent, mycophenolate, used to prevent tissue rejection, and rosuvastatin, which reduces cholesterol.Bread yeast is important in baking, but studies of bakers yeast also led to the discovery of basic cellular biochemistry and metabolism.In 1929 Alexander Fleming isolated substance from mold, and from there, penicillin was discovered. It was the first of a series of antibiotics derived directly from fungi that revolutionized the medical world from fungus was first used successfully to treat an infection caused by a bacteria in 1941. After this, many previously fatal diseases caused by bacteria became treatable.Several new groups of fungal agents have been discovered. The widely used antifungal agent Griseofulvin is derived from fungi. Griseofulvin is used to treat dermatophytes. It accumulates in the hair and skin following topical application.