Because Of The Highly Chemical and Physical Harsh Conditions in Marine Environment, The Organisms Produce A Spread of Molecules with Unique Structural Features and Exhibit Various Sorts of Biological Activities. Majority of The Marine Natural Products Are Isolated from Sponges, Coelenterates and A Wide Variety of Marine Micro-Organisms in Their Tissues. With 79% Of the Surface Covered by Water, Research into The Chemistry of Marine Organisms Is Comparatively Unexplored and Represents A Huge Resource for Brand Spanking New Medicines to Combat Major Diseases Such as Cancer, Aids or Malaria. Research Typically Focuses on Lessie Organisms or Slow-Moving Animals Due to Their Inherent Need for Chemical Defences. Standard Research Involves an Extraction of The Organism During A Suitable Solvent Followed by Either an Assay of This Crude Extract for A Specific Disease Target or A Rationally Guided Isolation of Latest Chemical Compounds Using Standard Chromatography Techniques. Marine Pharmacology May Be A Sub Branch Of Pharmacology Which Is Especially Concerned with The Present Substances of Medicinal Value from Marine. Generally, The Drugs Are Obtained from The Marine Species of Bacteria, Virus, Algae, Fungi and Sponges, Etc. Over 70% Of the Surface Is Roofed by Oceans Which Contain 95% Of the Earth's Biosphere. It Was Over 3500 Million Years Ago That Organisms First Appeared in The Sea.