Marine bacteria can cause harm to single-celled and multicellular eukaryotes. However, relatively little is understood about the underlying genetic basis for marine bacterial interactions with higher organisms. TCS systems link microbial physiology to the environment and thus may play key roles in biogeochemical cycles. Marine bacteria have an outsized number of “orphan” genes, also as many hybrid histidine kinases. In total, 15 phyla and 183 genera are represented from a spread of habitats, including coastal ecosystems, the open ocean, hydrothermal vent systems, host-associated environments, and marine sediments. TCS system genes were identified using highly conserved protein family domains for histidine kinases or response regulators as described in Materials and Methods. Antibiotic resistance has been increasingly reported for a wide variety of bacteria of clinical significance. As a results of the continual evolution of microbial pathogens towards antibiotic-resistance, there are demands for the event of latest and effective antimicrobial compounds.