Marfan syndrome could be a disorder that affects the animal tissue in several elements of the body. animal tissue provides strength and adaptability to structures like bones, ligaments, muscles, blood vessels, and heart valves. many of us with Marfan syndrome have further heart issues as well as a leak within the valve that connects 2 of the four chambers of the guts (mitral valve prolapse) or the valve that regulates blood be due the guts into the arteria (aortic valve regurgitation). Leaks in these valves will cause shortness of breath, fatigue, associated an irregular heartbeat felt as skipped or additional beats (palpitations). This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal. Journal with higher impact factor is considered to be more important than other ones.