Systemic LE may present with renal manifestations that regularly are difficult to categorize and lupus nephritis is a crucial predictor of poor outcome. the sort and spectrum of renal injury may remain undiagnosed until full-blown nephritic and/or nephrosis appear with increased risk of end-stage renal disease. These abnormalities occur within the primary few years after the diagnosis of lupus is formed on clinical grounds and with the support of laboratory tests in high risk patients. An early renal biopsy is useful in patients with an abnormal urinalysis and/or reduced glomerular filtration rate and therefore the results form the idea for therapeutic decisions. The biopsy also provides vital prognostic information supported histological categorization of various sorts of lupus nephritis, the degree of activity, chronicity and therefore the immunopathogenesis.