Loxoprofen is a nonsteroidal anti-inflammatory drug used in the treatment of many diseases. However, there are no case reports about loxoprofen-induced pneumonia. We have encountered a rare case of loxoprofen-induced pneumonia. Loxoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that alleviates inflammation and pain by nonselective inhibition of the cyclooxygenase pathway. Many clinicians worldwide routinely administer loxoprofen to patients with cold symptoms and acute upper respiratory inflammation. The major side effects of loxoprofen include gastric inflammation, ulcers, and renal dysfunction. However, development of interstitial pneumonia is a very rare side effect of loxoprofen. Here we report the first case of interstitial pneumonia induced by loxoprofen. The findings in this case report reveal an association between treatment with a nonsteroidal anti-inflammatory drug and pneumonia.