Despite the availability of efficacious treatment for several decenniums, leprosy remains a paramount medical quandary in many regions of the world. Infection with Mycobacterium leprae can engender paucibacillary disease, characterized by well-composed granulomas and a Th1 T-cell replication, or multibacillary disease, characterized by poorly organized cellular infiltrates and Th2 cytokines. These diametric immune replications confer states of relative resistance or susceptibility to leprosy, respectively, and have well-defined clinical manifestations. As a result, leprosy provides a unique opportunity to dissect the genetic substratum of human in vivo immunity. A series of studies over the past 40 years suggests that host genes influence the peril of leprosy acquisition and the predilection for different clinical forms of the disease. However, a comprehensive, cellular, and molecular view of the genes and variants involved is still being assembled. In this article, we review several decenniums of human genetic studies of leprosy, including a number of recent investigations. We accentuate genetic analyses that are validated by the replication of the same phenotype in independent studies or fortified by functional experiments demonstrating biological mechanisms of action for concrete polymorphisms. Identifying and functionally exploring the genetic and immunological factors that underlie human susceptibility to leprosy have yielded consequential insights into M. leprae pathogenesis and are liable to advance our construal of the immune replication to other pathogenic mycobacteria. This erudition may apprise incipient treatment or vaccine strategies for leprosy or tuberculosis. Among the genomic regions implicated in genetic susceptibility to leprosy is the sodality in 6q25, containing the gene regulatory region associated with Parkinson disease (PARK2) and co-regulator gene PACRG. Other amalgamations include changes anteriorly reported of a concrete gene for a natural resistance associated macrophage protein (NRAMP1), and withal a polymorphism in the vitamin D receptor gene (VDR). To increase the visibility and ease of use of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving services. Indexing provides easy access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports.