international journals in developing drugs  focus on current challenges in Pharmaceutical science..Drug Development within the parent particle which is having most extreme biological action has been recognized during the method of drug discovery and bringing a new pharmaceutical medicate to the advertise. It is the method by which the chemical compound is optimized at the seat on a milligram scale by a restorative chemist. It can be manufactured on the kilogram on huge scale. It is required to set up the physicochemical properties and quickened solidness thinks about of the modern chemical entity.