Cytokines may be peptides or glycoproteins involved in cell signaling secreted by specific immune cells. Cytokines regulate inflammation, trauma, sepsis, and infections. Cytokines play a major role in the immune response. Journal of Cytokine Biology focuses on areas such as interleukins, chemokines, monokines, interferons, and lymphokines. Articles on the immune response based on cytokines, the balance between innate and cell-based immune responses, receptor binding studies involving cytokines, techniques used for studying cytokine function. Detection of cytokine production, gene expression of cytokines, protein therapeutics based on cytokine mechanisms, application of transgenesis in the study of cytokinesis also welcome. Journal of Cytokine Biology is using Editorial Manager System for quality in the review process. Editorial Manager is an online manuscript submission, review, and tracking systems used by most of the best open access journals. Review processing is performed by the editorial board members of Journal or outside experts; at least two independent reviewers approval followed by editor's approval is required for acceptance of any citable manuscript.