Genome-wide affiliation contemplates have distinguished normal hereditary variations affecting human maladies; be that as it may, there are signs that the practical results of hereditary polymorphisms can be unmistakable relying upon cell type–explicit settings, which produce disparate phenotypic results. In this way, the useful effect of hereditary variety and the fundamental instruments of sickness chance are changed by cell type–explicit impacts of genotype on obsessive phenotypes. In this investigation, we stretch out these ideas to question the relationship of cell type–and incitement explicit projects impacted by the center autophagy quality Atg16L1 and its T300A coding polymorphism distinguished by genome-wide affiliation concentrates as connected with expanded danger of Crohn's malady. We applied an incitement based perturbational profiling way to deal with characterize Atg16L1 T300A phenotypes in dendritic cells and T lymphocytes. Appropriately, we recognized boost explicit transcriptional marks uncovering T300A-subordinate utilitarian phenotypes that robotically interface provocative cytokines, IFN reaction qualities, steroid biosynthesis, and lipid digestion in dendritic cells and iron homeostasis and lysosomal biogenesis in T lymphocytes. Aggregately, these investigations feature the joined impacts of Atg16L1 hereditary variety and stimulatory setting on insusceptible capacity.