Immunodeficiency is a condition where your body can't deliver enough substances to battle against a contamination or a piece of the insusceptible is missing. Immunodeficiency can likewise be characterized as weakness of the resistant reaction. In this condition the individual is increasingly inclined to diseases that are commonly progressively serious and keeps going longer when contrasted with the typical contaminations. Body's principle framework in battling against diseases is resistant framework. We are brought into the world with natural insusceptibility and versatile resistance creates for the duration of the life. Immunodeficiency diaries manages safe reaction and sicknesses. Immunodeficiency or safe inadequacy is a state where the safe framework's capacity to battle irresistible sickness is undermined or altogether missing. The invulnerable framework shields the body from conceivably hurtful substances called antigens. Immunodeficiency can be followed to the disappointment of at least one pieces of the insusceptible framework. Immunodeficiency can be grouped into two kinds: essential immunodeficiency brought about by inborn/acquired deformities or optional immunodeficiency brought about by an ailment that influences the invulnerable framework. Most instances of immunodeficiency are optional however a few people are brought into the world with surrenders in their resistant framework, or essential immunodeficiency. Diary of Primary and Acquired Immunodeficiency Research distributes aftereffects of exploration on Primary Immunodeficiency, Acquired Immunodeficiency, Diseases/Infections/Disorders related with Immunodeficiency, and their Treatments.