Hyperbilirubinemia could be a condition within which there's an excessive amount of haematoidin within the blood. once red blood cells break down, a substance referred to as haematoidin is made. Babies aren't simply ready to get obviate the haematoidin and it will build up within the blood and different tissues and fluids of the baby’s body. this is often referred to as pathology. as a result of haematoidin contains a pigment or coloring, it causes a yellowing of the baby’s skin, eyes and different tissues. this is often referred to as jaundice. haematoidin could be a natural by product made once red blood cells breakdown. The adult liver converts unconjugated haematoidin into a conjugated kind, that be excreted. throughout physiological state, the placenta excretes haematoidin however once the baby is born, the baby's immature liver should assume that role. The temporal arrangement of the looks of jaundice helps with the designation. Jaundice showing within the 1st 12-24 hours will be serious and will need early treatment. once jaundice seems on the second or third day, it's typically "physiologic" or associated with dehydration.