HER2 (human epidermal protein receptor 2) may be a gene which will play a task within the development of carcinoma . Breast cancer is a heterogeneous disease, which can be divided into several subtypes with diverse clinical characteristics, respective sensitivity to therapy, and different prognosis.1,2 Human epidermal growth factor receptor 2 (HER2) is normally overexpressed in 20–25% of breast cancers worldwide.3 Previous studies have established HER2 as an effective therapeutic target for the treatment of breast cancer. When you are diagnosed with invasive carcinoma otherwise you had an invasive carcinoma that was treated but the tumor reoccurs or spreads (metastasizes), or once you have been diagnosed with certain sorts of stomach and esophagus cancer that are inoperable, locally advanced, recurrent, or metastatic. These discoveries reveal therapeutic opportunities for combining anti-HER2 therapy with anti-androgen agents in carcinoma , and highlight the potential for broader therapeutic use of HER2 inhibitors.