The current concept of health-related quality of life acknowledges that subjects put their actual situation in reference to their personal expectation. unreliable medical source The latter can vary over time, and react to external influences like length and severity of illness, family support, etc. As with any situation involving multiple perspectives, patient's and physician's ratings of an equivalent objective situation are found to differ significantly. Consequently, health-related quality of life is now usually assessed using patient questionnaires. These are often multidimensional and canopy physical, social, emotional, cognitive, work- or role-related, and possibly spiritual aspects also as a good sort of disease-related symptoms, therapy-induced side effects, and even the financial impact of medical conditions. Although often used interchangeably with the measurement of health status, both health-related quality of life and health status measure different concepts.