Immunogenetics is a subspeciality of medication that reviews the connection among hereditary qualities and immunology. Immunogenetics helps in understanding the pathogenesis of a few immune system and irresistible maladies. Guillain-Barre condition (GBS) is an intense demyelinating provocative intervened polyneuropathy interceded by the safe framework that prompts summed up limp loss of motion. Most GBS cases are gone before by viral or bacterial diseases of the respiratory or gastrointestinal tract, building up an atypical reaction that causes autoantibody arrangement and supplement and cytokine actuation. Since it is an uncommon malady, determination is frequently moderate and may decline the clinical picture. The patient ought to be assessed by a multidisciplinary group and the treatment of decision is intravenous human immunoglobulin. We report a case where the patient had a few indications coming about because of GBS, most likely created by the past contamination, yet just had the infection analyzed late, prompting an exacerbating of her clinical condition and bargaining her personal satisfaction. Since 1976, a few examinations have built up a causal connection among GBS and immunizations, particularly Influenza A, yet the pathophysiological system stays obscure. Notwithstanding, it is realized that there is a more noteworthy possibility of GBS improvement because of Influenza an infection contamination than immunization. Studies uncover that there are ecological and hereditary segments that may impact vulnerability to ailment. Be that as it may, there is little examination on the polymorphism of safe reaction qualities and their impact on the improvement of the condition. A few instances of contribution of individuals having a place with a similar family have been accounted for in the writing, in this manner exhibiting that the nearness of hereditary segments impacting the inclination to GBS can't be precluded.