Glioblastoma multiform (GBM) is the most highly invasive and malignant primary encephalon tumour in humans with median survival after diagnosis as low as 12-15 months. The poor prognosis of GBM is attributable to its resistance to current therapeutic approaches, consisting of maximal debunking surgery, chemotherapy with temozolomide, and radiotherapy. Amongst the heterogeneous population of tumour cells found in GBM, a self-renewing and proliferating cell type kenned as glioma stem-like cells (GSC) has been identified as a potential source for glioma therapy resistance. It has been well documented that current therapies fail to efficaciously eliminate GSC from the tumour population. This contributes to the virtually inevitably ineluctable tumour recurrence in GBM patients following treatment. Consequently, GSC provides a concretely alluring target for the development of future therapies. This review highlights several proposed mechanisms behind therapy resistant glioma cells including DNA repair mechanisms, cell cycle checkpoints, drug efflux processes, and the role of the tumour microenvironment. To increase the visibility and ease of use of open access scientific and scholarly journals top online publishing journals are indexed in different indexing and archiving services. Indexing provides easy access of the article online. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports. The inclusion of these publications provides the opportunity for editors and publishers to manipulate the ratio used to calculate the impact factor and try to increase their number rapidly. Impact factor plays a major role for the particular journal.