Leprosy, a chronic granulomatous infectious disease caused by acidbacilli (AFB) resistant Mycobacterium leprae (M. leprae) mainly infects skin macrophages and Schwann cells in nerves. Thus, leprosy can be visually perceived as two coalesced disorders: one characterized by a chronic infection that depends on the competency of host immune replication and the other being a peripheral neuropathy which commences during infection, but with consequences which may elongate for many years after remedy. In leprosy the paramountcy of the host replication to infection is illustrated by the broad clinical spectrum visually examined amongst those that develop disease. At one pole is tuberculoid leprosy, characterized by vigorous cell-mediated immunity, a Th1 CD4+ cytokine profile very few bacteria and localized lesions. At the other pole is lepromatous leprosy, characterized by a lack of cell-mediated immunity, Th2 CD4+ replications (IL4 and IL5), a vigorous humoral replication, disseminated progressive disease and immensely colossal numbers of bacteria. Thus tuberculoid patients can be thought of as those exhibiting the most resistance whereas lepromatous patients are those exhibiting the least. This is not to verbally express that the pathogenesis associated with the more resistant pole is indispensably milder; vigorous Th1 replications that contain the bacterium can result in expeditious and rigorous nerve damage. It has been widely surmised for many infectious diseases, including leprosy, that susceptibility is governed by polygenic inheritance, or the additive effect of multiple genes, each with a modest effect on the infectious phenotype. Two study designs are typically used to examine diseases with intricate inheritance patterns: linkage studies of families and sodality studies (candidate gene or genome wide). Linkage studies look for evidence of the segregation of a genetic marker and a disease trait within families. Genetic sodality studies assess whether the frequency of a particular genetic variant differs between individuals with a disease compared to unrelated controls. Thus far all the genes suggested to have a role in the susceptibility to leprosy either act to directly modulate development of the adaptive replication (HLA, MICA, TAP2, CTLA4, VDR), or may bridge the innate and adaptive replications (NRAMP1, TLR2, HSP70, TNF, MRC1). This is consistent with the conception that a felicitous cell-mediated replication is critical in the control of mycobacterial infection. The top online publishing journals publish articles which are cited as references by many authors in their work. Citations are important for a journal to get impact factor. Impact factor is a measure reflecting the average number of citations to recent articles published in the journal. The impact of the journal is influenced by impact factor, the journals with high impact factor are considered more important than those with lower ones. Indexing provides easy access of the article online. The international journals are among the best open access journals in the world, set out to publish the most comprehensive, relevant and reliable information based on the current research and development on a variety of subjects. This information can be published in our peer reviewed journal with impact factors and are calculated using citations not only from research articles but also review articles (which tend to receive more citations), editorials, letters, meeting abstracts, short communications, and case reports.