Osteoarthritis (OA) is the most not unusual form of arthritis and is characterized by using harm or breakdown of articular cartilage in load-bearing joints, in particular inside the knees, hips and hands. The disorder is one of the main reasons of disability worldwide and results in ache, stiffness, joint deformity and loss of joint mobility, which frequently expand slowly over time. There are some of hazard factors related to OA, together with age, obesity, metabolic ailment, preceding joint harm, bizarre joint loading and biomechanics, genetics and systemic infection. However, OA predominantly affects older humans, often co-present with different comorbid situations associated with growing older.Read the published content material on this thematic series covering all elements of studies into osteoarthritis from studies investigating the underlying pathophysiological mechanisms through to the ones describing clinical practice.