Fluorescence in situ hybridization is a molecular cytogenetic technique that uses fluorescent probes that bind to only those elements of a nucleic acid sequence with a excessive degree of collection complementarity. It turned into developed by way of biomedical researchers in the early 1980s to hit upon and localize the presence or absence of precise DNA sequences on chromosomes. Fluorescence microscopy may be used to find out wherein the fluorescent probe is sure to the chromosomes. FISH is frequently used for locating unique functions in DNA to be used in genetic counseling, medicinal drug, and species identification. FISH can also be used to locate and localize unique RNA objectives (mRNA, lncRNA and miRNA) in cells, circulating tumor cells, and tissue samples. In this context, it may assist define the spatial-temporal patterns of gene expression inside cells and tissues. Fluorescence insitu hybridization has been a successfully publishing quality Research article from many years and looking forward to frame up eminent, outstanding issues with best quality research articles in this year. We request you to kindly submit and publish your paper in this best journal and get global acknowledgment.