. A number of computer simulation and other models have been recommended for use as alternatives to use of animals for pharmacology education. In this review we also discuss some of these alternatives.He missions of medicine is to eliminate suffering to maintain a good health, which may prolong the life. Drugs, an important tool in healthcare, are introduced in therapeutics after experimental evaluation. Since the beginning of humanity, the nature of human mind has led man to exploit his environment for his own requirements. Amidst endless efforts to expand his knowledge about living organisms, himself included, he began using animals for experimentation. Animal experiments, for long, have been an integral part of the pharmacology education at medical colleges in India. Thousands of animals are used annually in educational institutes despite efforts by concerned teachers and activists to reduce this number. Many medical schools in India and other countries have either introduced alternatives to these experiments or are deliberating on this contentious issue