The size of the microbial world is past our creative mind. In a year ago's precious stone ball article, Tom Curtis thought about the size of the microbial world to the size of the universe calling attention to that the quantity of microorganisms on the planet is billions of times bigger than the quantity of stars in the sky (Curtis, 2007). There is little uncertainty that such boundless microbial biodiversity holds extraordinary guarantee for advancing our collection of known proteins, with numerous novel compounds anticipating revelation. The improvement of new advanced sequencing advances, including the 454 pyrosequencer and Solexa innovation, consider aggregation of amazingly a lot of grouping data. Such quickly collected data will permit microbiologists, bio‐informaticians and framework scientists to perform broad studies on microbial ancestries, lead to the portrayal of new metabolic pathways and take into account the distinguishing proof of new administrative instruments. These information likewise speak to an important asset as we continued looking for new catalysts. Still the topic of how would we really locate these valuable needles in the enormous sheaf emerges. In particular, what will be the most ideal approach to discover new compounds in the immense space that is the microbial world.