Longstanding disease of the kidneys leading to renal failure.The kidneys filter waste and excess fluid from the blood. As kidneys fail, waste builds up.Symptoms develop slowly and aren't specific to the disease. Some people have no symptoms at all and are diagnosed by a lab test.Medication helps manage symptoms. In later stages, filtering the blood with a machine (dialysis) or a transplant may be required.

Dialysis and ESRD Life ExpectancyFor individuals aged 30 to 35 years, their life expectancy is 14 years for males and 13 years for females. Those aged between 70 and 75 years have a life expectancy of 4 years for both males and females.End-stage renal disease, also called end-stage kidney disease, occurs when chronic kidney disease — the gradual loss of kidney function — reaches an advanced state. In end-stage renal disease, your kidneys are no longer able to work as they should to meet your body's needs.

Stage 5 CKD. A person with Stage 5 CKD has end stage renal disease (ESRD) with a GFR of 15 ml/min or less. At this advanced stage of kidney disease the kidneys have lost nearly all their ability to do their job effectively, and eventually dialysis or a kidney transplant is needed to live.In the United States the two leading causes of kidney failure, also called end stage kidney disease or ESRD, are diabetes (also called Type 2, or adult onset diabetes) and high blood pressure. When these two diseases are controlled by treatment, the associated kidney disease can often be prevented or slowed down.