Stem Cells focus totally on the useful and mechanistic aspects of somatic cell biology and therefore the potential of various kinds of stem cells for therapeutic applications. The journal publishes key, well-controlled advances in somatic cell clinical trials and mechanism-based manuscripts with definitive conclusions. Single‐cell transcriptome‐based biological process trajectories reveal biological process abnormalities in eye disease eye disease retinal neural structure cells (RGCs). A comparison of the biological process trajectories, supported signature of differentiating eye disease patient )‐specific and management elicited pluripotent stem cells on the RGC lineage, unconcealed that the This study incontestable that human dental medicine dental medicine stem cells (PDLSCs) scale back retinal neural structure cells (RGC) degeneration elicited by optic tract injury and promote nerve fiber regeneration in rats. Human PDLSCs conjointly enhance RGC survival and neurite outgrowth within the retinal explant culture model through direct PDLSC‐RGC interaction and neurotrophic issue secretion from human PDLSCs. Schematic of hypothetic signal cascade. The cell fate of CPCs changes with age and is characterized by a switch aloof from proliferation and quiescence toward senescence and accumulated basal commitment accounting for age‐associated somatic cell exhaustion. RGCs square measure compromised in mature composition and subtype composition, as well as those who those who vs controls.