Drug dependence occurs when you need one or more drugs to function. The abuse was considered the mild or early phase of inappropriate drug use that led to dependence. People viewed dependence as a more severe problem than abuse.
It’s possible to be dependent on drugs without being addicted. Dependence can be a bodily response to a substance. This often occurs if you rely on medications to control a chronic medical condition. These conditions may include:

high blood pressure diabetes glaucoma

Dependence may involve:

some or all the symptoms of addiction
development of a high tolerance for the substance as your body adapts to the drug, leading to a desire for larger or more frequent doses
physical symptoms of withdrawal when you attempt to stop using the drug. The open access journals are peer reviewed scholarly journals of Biochemical engineering. The top open access Biochemical engineering journals are freely available on the public internet domain, allowing any end users to read, download, copy, distribute, prink, search or link to the full texts of the articles.