Tuberculosis remains one in every of the highest 3 communicable disease killers. The prevalence of multidrug-resistant TB (MDR-TB) has magnified considerably within the past twenty years. once drug resistance isn't detected, MDR-TB patients cannot access life-saving treatment; this puts their communities in danger of current MDR-TB transmission. we have a tendency to aimed to work out the patterns of resistance to antituberculosis medicine among Mycobacterium tuberculosis isolates from Khuzestan province in Iran. TB is that the most rife infection worldwide. The emergence of drug-resistant Mycobacterium tuberculosis (M. tuberculosis) isolates emphasizes that it's necessary to watch drug resistance of the organism against anti-tubercular medicine. we have a tendency to analyzed 327 M. TB isolates from patients UN agency were cared for at 3 totally different health care centers, hereunder referred to as study areas