Drosophila melanogaster has been established as a cornerstone for research into a  wide array  of subjects  including diseases,  development, physiology, and genetics. Thanks to an abundance of genetic tools, publicly available  stocks, and databases,  as  well  as  their considerable  biological  similarity to  mammalian  systems, Drosophila  has  been solidied  as  a  key model organism  for  elucidating many  aspects of human disease.  Herein is  presented  an overview of  what makes  Drosophila  such an appealing model organism.